Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats
Our studies showed MFLX more likely to cause hyperglycemia when used in diabetic states and highlighted the critical role of gut microbiota-SBAs-TGR5/FXR pathway in MFLX-induced hyperglycemia.
Authors
- Ziyan Du
- Yunli Yu (ORCID: https://orcid.org/0000-0002-0811-3267)
- Zhuan Yang
- Jie Pan (ORCID: https://orcid.org/0000-0001-9245-0700)
- Bo Lv (ORCID: https://orcid.org/0000-0001-7422-1816)
- Kai Fan
- Guanjun Wang (ORCID: https://orcid.org/0000-0003-1364-8933)
- Yuchen Qu (ORCID: https://orcid.org/0000-0002-0649-3147)
- Yewen Sun
- Yuyuan Wang
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.3389/fphar.2025.1569856
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Pharmaceutical Association
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Soochow University
- Second Affiliated Hospital of Soochow University