Cytotoxicity-guided isolation of elatostemanosides I–VI from <i>Elatostema tenuicaudatum</i> W. T. Wang and their cytotoxic activities

<i>Elatostema tenuicaudatum</i> W. T. Wang, a medicinal plant traditionally utilized in herbal remedies, was explored for its cytotoxic properties. Bioassay-guided fractionation led to the discovery of six novel compounds, designated as elatostemanosides I-VI, with their structures elucidated through advanced spectroscopic methods and DP4+ analysis. Among these, compounds 2, 5, and 6 demonstrated moderate cytotoxicity against the human liver cancer cell line HepG2, exhibiting IC<sub>50</sub> values of 18.2 ± 2.1, 32.1 ± 0.4, and 57.6 ± 1.3 µM, respectively. Notably, compound 6 also displayed significant activity against the human breast cancer cell line HCC1806, with an IC<sub>50</sub> value of 35.4 ± 0.3 µM. Mechanistic studies revealed these compounds induced apoptosis by modulating the Bax/Bcl-2 ratio. Furthermore, structure-activity relationship (SAR) analysis underscored the importance of specific functional groups in mediating cytotoxic effects.

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Publication Details

Journal
RSC Advances
Published
2025-01-01
DOI
https://doi.org/10.1039/d4ra09007a
Citations
4
Primary Topic
Phytochemistry and Biological Activities
Type
article
Field-Weighted Citation Impact
7.00

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article

Cytotoxicity-guided isolation of elatostemanosides I–VI from Elatostema tenuicaudatum W. T. Wang and their cytotoxic activities

Yunhan Wang, Yao Shen, Su-Jung Hsu, Man-Hsiu Chu et al.
4 citations
RSC Advances
Phytochemistry and Biological Activities
7.00
article

Cytotoxicity-guided isolation of elatostemanosides I–VI from Elatostema tenuicaudatum W. T. Wang and their cytotoxic activities

Yunhan Wang, Yao Shen, Su-Jung Hsu, Man-Hsiu Chu, Thanh‐Hoa Vo, Yu‐Jui Fan, Ching‐Chuan Kuo, Ching‐Kuo Lee, Dang-Khoa Nguyen, Ta-Wei Liu, Thanh-Vu Nguyen, Thuy-Tien Thi Phan, Truc-Ly Thi Duong, Quoc-Dung Tran Huynh
article en
4 citations

Abstract

<i>Elatostema tenuicaudatum</i> W. T. Wang, a medicinal plant traditionally utilized in herbal remedies, was explored for its cytotoxic properties. Bioassay-guided fractionation led to the discovery of six novel compounds, designated as elatostemanosides I-VI, with their structures elucidated through advanced spectroscopic methods and DP4+ analysis. Among these, compounds 2, 5, and 6 demonstrated moderate cytotoxicity against the human liver cancer cell line HepG2, exhibiting IC<sub>50</sub> values of 18.2 ± 2.1, 32.1 ± 0.4, and 57.6 ± 1.3 µM, respectively. Notably, compound 6 also displayed significant activity against the human breast cancer cell line HCC1806, with an IC<sub>50</sub> value of 35.4 ± 0.3 µM. Mechanistic studies revealed these compounds induced apoptosis by modulating the Bax/Bcl-2 ratio. Furthermore, structure-activity relationship (SAR) analysis underscored the importance of specific functional groups in mediating cytotoxic effects.

RSC AdvancesVol. 15(14)
Vietnam National University Ho Chi Minh City (VN), Ton Duc Thang University (VN), Chung Yuan Christian University (TW), National Health Research Institutes (TW), National Taiwan University (TW), Can Tho University (VN), Bình Dương University (VN), Taipei Medical University (TW)
Ministry of Science and Technology, Taiwan, Taipei Medical University, National Taiwan University
Zero hunger
Openalex Percentile: Top 4%
Phytochemistry and Biological Activities
7.00
DOIOpen Access PDFOpenAlex
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