A response to iron involving carbon metabolism in the opportunistic fungal pathogen <i>Candida albicans</i>
We describe a new response to Fe-starvation in a fungal pathogen involving carbon metabolism. Pyruvate dehydrogenase (PDH) that is central to glucose metabolism is inactivated at the post-translational level in Fe-starved cells. Nevertheless, the fungal pathogen can thrive by activating backup systems for metabolizing glucose. Methods that inhibit these compensatory pathways for carbon metabolism may prove beneficial in future anti-fungal strategies.
Authors
- Vincent M. Bruno (ORCID: https://orcid.org/0000-0003-1683-2015)
- Zhengkai Zhu
- Yiran Wang (ORCID: https://orcid.org/0000-0003-1263-3860)
- Francisco Hernandez
- Valeria Culotta (ORCID: https://orcid.org/0000-0002-3213-1326)
- Marika S. David
- Ritu Garg (ORCID: https://orcid.org/0009-0007-0291-6839)
Institutions
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
Publication Details
- Journal
- mSphere
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1128/msphere.00040-25
- Citations
- 5
- Primary Topic
- Fungal and yeast genetics research
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Institutes of Health