Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression
These findings suggest that FSH promotes ALKBH5 expression, facilitates N<sup>6</sup>-methyladenosine (m6A) demethylation on FOXM1, and consequently, induces EndMT. This study elucidates the impact of FSH on plaque instability and provides insights into potential strategies to prevent acute coronary syndrome in postmenopausal women.
Authors
- Xingyan Xu (ORCID: https://orcid.org/0000-0002-4802-8542)
- Xiaodong Fu (ORCID: https://orcid.org/0000-0003-2754-8976)
- Hui‐Ping Lin (ORCID: https://orcid.org/0000-0003-4437-1631)
- Jinzhi Wei
- Ping Li (ORCID: https://orcid.org/0000-0001-6048-181X)
- Haowei Yu
- Yixiao Xiang
- Xiaosa Li (ORCID: https://orcid.org/0000-0002-0451-002X)
- Jiale Wang (ORCID: https://orcid.org/0009-0006-3817-6644)
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s11658-025-00720-y
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Guangzhou Medical University
- National Natural Science Foundation of China