Plasma cytokine levels and PCOS risk: Mendelian randomization analysis reveals IL6R as a preventive factor
Our Mendelian randomization analysis, leveraging genome-wide association study data from a sizable population cohort, unequivocally delineated a causal relationship between IL6R and PCOS. These results underscore the involvement of cytokines in the pathogenesis of PCOS and highlight their potential as promising therapeutic targets for addressing this intricate disease.
Authors
- Yongrui Du (ORCID: https://orcid.org/0000-0003-2626-0938)
- Xiaopei Li (ORCID: https://orcid.org/0000-0002-4438-9439)
- Bumei Zhang
- Yan Li (ORCID: https://orcid.org/0000-0002-8856-4083)
- Yang Yang (ORCID: https://orcid.org/0000-0002-0273-9242)
- Jianmei Wang (ORCID: https://orcid.org/0000-0003-2811-4344)
Institutions
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1186/s13048-025-01647-w
- Citations
- 1
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.70