Early-Life Exposure to Acid-Suppressive Therapy and the Development of Celiac Disease Autoimmunity
This retrospective study included both cohort and test-negative case-control designs. In the cohort design, acid-suppressive therapy was significantly associated with celiac disease autoimmunity. In the test-negative case-control design, this association was not significant. These results suggest a residual confounding by health care utilization in cohort designs studying celiac disease and suggest a noncausal association between acid-suppressive therapy and celiac disease autoimmunity.
Authors
- Amir Ben‐Tov (ORCID: https://orcid.org/0000-0001-9627-7626)
- Tomer Achler (ORCID: https://orcid.org/0000-0003-2620-9630)
- Ron Shaoul (ORCID: https://orcid.org/0000-0001-5667-8759)
- Sivan Gazit (ORCID: https://orcid.org/0000-0001-9875-3550)
- Tal Patalon (ORCID: https://orcid.org/0000-0001-7415-1053)
- Shlomi Cohen (ORCID: https://orcid.org/0000-0002-6190-3217)
Institutions
- Tel Aviv University (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Rambam Health Care Campus (IL)
- Maccabi Healthcare Services (IL)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.3376
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00