Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson’s disease
This study elucidates the pathogenic role of OS-induced disulfidptosis in PD progression. By identifying novel diagnostic biomarkers (e.g., DED-ORGs) and therapeutic targets (e.g., LRPPRC), our findings provide a mechanistic framework for PD management and lay the groundwork for future therapeutic development.
Authors
- Jianshe Wei (ORCID: https://orcid.org/0000-0002-3560-3392)
- Tingting Liu (ORCID: https://orcid.org/0000-0003-3671-2782)
- Haojie Wu (ORCID: https://orcid.org/0000-0003-0293-458X)
- Qiumin Qu (ORCID: https://orcid.org/0000-0002-5634-6209)
- Junshi Zhang
Institutions
- Henan University (CN)
- Henan University Huaihe Hospital and Huaihe Clinical Institute (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Molecular Brain
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s13041-025-01200-2
- Citations
- 7
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 9.48
Funders
- Strong
- National Natural Science Foundation of China
- Henan University
- Science and Technology Department of Henan Province
- Natural Science Basic Research Program of Shaanxi Province