Current issue of children’s congenital disorders, long term consequences (literature review and case report)

Annotation. There is significant rising of morbidity rate and decreasing amount among children population in Ukraine. In the same time the count of preterm and low body weight newborns steady grow up too. Moreover, there is a tendency of a rising frequency of congenital abnormalities, deformations, chromosome aberrations among the reasons of morbidity and mortality rate in toddlers. That is why intrauterine development of the fetus couses concern by pediatrician society. The treatment and diagnosis outcomes were applied to make conclusion about clinical features of the term 7-month-old girl with chromosome 18 deletion and the data were analyzed using PubMed/Medline and Google Scholar databases too. The bibliosemantic method was used to find out of information for the current view of congenital malformations and their long-term consequences. The key words were used: “congenital malformations”, “chromosomal aberrations”, “childhood morbidity and mortality”. The aim of article is to summarize particulars of congenital abnormalities, phenotype by chromosome 18 deletion baby, providing of physician with practical information regarding organize follow-up. Congenital heart disease (Tetralogy of Fallot), hydrocephalia, stenosis of sublingual space, gastro esophageal reflux, acute pneumonia, hypotrophya were diagnosed in the child with chromosome 18 deletion and it is correspondently to data of literature review. These patients suffer from humoral and cells immune system insufficiency too. So that infections like viruses and bacteria complicated general condition of the child. Clinical features of chromosome 18 deletion are rich it's necessary to keep phenotypes sings to make conclusion about disease. Generally, child with congenital disorder needs support vital function, symptomatic treatment, palliative care. Perspective of future investigation consists of a search mechanism of preventing congenital abnormalities and methods of earlier diagnosis