Profiles of neutrophilic intestinal inflammation and endothelial dysfunction in patients with inflammatory bowel disease

Annotation. The high level of perinatal pathology of placental genesis, determined by inflammatory bowel diseases (IBD), determines the relevance of the conducted study. The purpose of the study is to analyze indicators of neutrophilic intestinal inflammation and endothelial dysfunction from the point of view of their participation in the development of perinatal pathology of placental origin in IBD. 40 patients with IBD in stable remission were examined, who constituted the clinical study group and 30 practically healthy women of the control group. The following were determined: fecal calprotectin, homocysteine, serum levels of tumor necrosis factor α (TNFα), interleukin-4 (IL4), C-reactive protein (CRP), platelets, fibrinogen, endothelial status was assessed (endothelium-dependent vasodilation (EDV), vascular endothelial growth factor (VEGF) and microalbuminuria (MAU)), laboratory parameters (hemoglobin, erythrocytes, ferritin, ESR). The mean (M) and standard error of the mean (±m) were calculated using the STATISTICA 6.1 (No. AXHR910F374605FA) and MedCalc (version 17.7.7, MedCalc Software) software packages. The obtained results of the study of pregnant women with IBD in remission indicate the development of endothelial dysfunction in them, which was manifested by changes in microalbuminuria indicators, the level of vascular endothelial growth factor and the index of endothelium-dependent vasodilation. In addition, an increase in the level of pro-inflammatory cytokines tumor necrosis factor and interleukin-4, as well as homocysteine in the blood serum of such patients was found. Thus, the results of the study can be included as a component of a non-invasive strategy for monitoring patients with inflammatory bowel diseases in remission, to control perinatal complications of placental origin.