Risk factors, impact on outcomes, and molecular epidemiology of infections caused by carbapenem-resistant Enterobacterales in intensive care patients: a multicenter matched case–control study in Brazil
Carbapenem-resistant Enterobacterales-related infections in intensive care unit patients were associated with major premorbid dependence, intensive care unit readmission, and acute COVID-19. In addition, carbapenem-resistant Enterobacterales infections were independently associated with poorer hospital outcomes. This study also characterized the resistance profile of Enterobacterales in Brazilian intensive care units, which are dominated by K. pneumoniae with high rates of carbapenemase and increased rates of New Delhi metallo-beta-lactamase, in comparison with previous reports.
Authors
- Bianca Brandão de Paula Antunes (ORCID: https://orcid.org/0000-0003-4220-0185)
- Leonardo dos Santos Lourenço Bastos (ORCID: https://orcid.org/0000-0001-7833-0403)
- Sílvio Hamacher (ORCID: https://orcid.org/0000-0002-3980-0342)
- Pedro Fernandez Del Peloso (ORCID: https://orcid.org/0000-0001-9309-0540)
- Fernando A. Bozza (ORCID: https://orcid.org/0000-0003-4878-0256)
- Pedro Kurtz (ORCID: https://orcid.org/0000-0002-4469-8645)
Institutions
- Pontifícia Universidade Católica do Rio de Janeiro (BR)
- D’Or Institute for Research and Education (BR)
- Instituto Estadual do Cérebro Paulo Niemeyer (BR)
Publication Details
- Journal
- Critical Care Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.62675/2965-2774.20250237
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39