Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway
Galangin supresses Beclin-1-dependent autophagy and upregulates the PI3K/AKT signaling pathway to attenuate the neuroinflammatory injury and improve motor coordination ability in PD mice induced by MPTP.
Authors
- Minzhen Deng (ORCID: https://orcid.org/0000-0003-3815-9984)
- Zhongliu Zhou
- Shuyu Xie (ORCID: https://orcid.org/0000-0003-0381-2509)
- Yingying He (ORCID: https://orcid.org/0000-0002-9007-5983)
- Jingyi Wu
- Qiaofeng Li (ORCID: https://orcid.org/0000-0003-2595-5551)
- Junwei Huang (ORCID: https://orcid.org/0000-0003-2005-0630)
- Liping Huang (ORCID: https://orcid.org/0000-0003-3466-5097)
- C.‐H. Yang (ORCID: https://orcid.org/0000-0002-7180-7798)
- Qinyun Ruan
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Lingnan Normal University (CN)
- Key Laboratory of Guangdong Province (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-04
- DOI
- https://doi.org/10.3389/fnagi.2025.1568002
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.42