Gold-Catalyzed Regio- and Diastereoselective [3 + 2] Cycloaddition/Unactivated C(sp<sup>3</sup>)–H Bond Insertion of <i>o</i>-1,6-Enynyl Benzaldehydes to <i>Oxa</i>-Bridged Polycycles
An efficient and expeditious method to assemble <i>oxa</i>-bridged polycycles bearing up to six contiguous stereocenters from a gold(I)-catalyzed [3 + 2] cycloaddition/unactivated C(sp<sup>3</sup>)-H bond insertion cascade of <i>o</i>-1,6-enynyl benzaldehydes at a low catalyst loading of 2 mol % is described.
Authors
- Rui Hu (ORCID: https://orcid.org/0000-0003-4949-6214)
- Weidong Rao (ORCID: https://orcid.org/0000-0002-6088-7278)
- Philip Wai Hong Chan (ORCID: https://orcid.org/0000-0002-8786-6143)
- Xiaowen Ji (ORCID: https://orcid.org/0000-0002-0507-7520)
- Yongsheng Zhang (ORCID: https://orcid.org/0000-0001-7214-209X)
Institutions
- Nanjing Forestry University (CN)
- Australian Regenerative Medicine Institute (AU)
- Monash University (AU)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c00891
- Citations
- 1
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Jiangsu Provincial Department of Education
- Australian Research Council