Preoperative consecutive treatment with isoprenaline and adenosine is safe and reduces ischaemia-reperfusion injury in a porcine model of cardiac surgery with recent acute myocardial infarction
The therapy was feasible and safe and improved biomarkers of efficacy. ISO/ADE was not associated with any postoperative low cardiac output and deaths versus 37.5% and 25%, respectively, in the control group. A pilot human study is warranted.
Authors
- Daniel Baz-Lopez (ORCID: https://orcid.org/0000-0003-4452-8125)
- Igor Khaliulin (ORCID: https://orcid.org/0000-0003-2278-5892)
- Raimondo Ascione (ORCID: https://orcid.org/0000-0001-8045-5619)
- Vito Domenico Bruno (ORCID: https://orcid.org/0000-0002-8193-9559)
- Eva Sammut (ORCID: https://orcid.org/0000-0002-4198-6860)
- Ettorino Di Tommaso (ORCID: https://orcid.org/0000-0003-4108-7897)
- M.Saadeh Suleiman (ORCID: https://orcid.org/0000-0001-6080-480X)
- Julia Deutsch (ORCID: https://orcid.org/0000-0002-7801-6147)
- Tom Johnson (ORCID: https://orcid.org/0000-0003-4638-601X)
- S.J.P. Smith
Institutions
- University of Bristol (GB)
- NIHR Bristol Biomedical Research Centre (GB)
- NIHR Bristol Cardiovascular Biomedical Research Unit (GB)
Publication Details
- Journal
- European Journal of Cardio-Thoracic Surgery
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1093/ejcts/ezaf120
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Heart Foundation
- Medical Research Council