Research progress on the effects of Lycium barbarum polysaccharides in metabolic diseases

Lycium barbarum polysaccharide (LBP) stands as the primary bioactive constituent of goji berries, attracting increasing attention for its potential in mitigating metabolic disorders. This paper provides a comprehensive overview of the structure and biological properties of LBP, with particular emphasis on its roles in anti-diabetic, anti-obesity, hepatoprotective, cardiovascular protective, neuroprotective functions and protective effects on skeletal muscle. This review provides a detailed examination of the current research progress on LBPs, elucidating their mechanisms of action and clinical implications in the context of metabolic disorders. We explore the diverse bioactive components of LBPs, their effects on various metabolic parameters, and the underlying molecular mechanisms involved. Additionally, we discuss challenges and opportunities for further research to fully harness the potential of LBPs in metabolic disease management. • Lycium barbarum polysaccharide (LBP) is the key bioactive compound in goji berries, known for its therapeutic potential in metabolic disorders. • LBP exhibits anti-diabetic, anti-obesity, hepatoprotective, cardioprotective effects,neuroprotective, and skeletal muscle protective properties. • Current research on LBP's effects and molecular mechanisms is discussed in detail, focusing on its clinical implications. • Challenges and opportunities for advancing LBP research in the management of metabolic diseases are highlighted.