Phase I Study of Subcutaneous Rituximab Hyaluronidase Combined With CHOP Chemotherapy for the Treatment of Diffuse Large B-Cell Lymphoma in Uganda
As demonstrated in other parts of the world, sqR together with CHOP was safe, well-tolerated, and efficacious among Ugandan patients with DLBCL. The very high OS rates are nearly double those of historical controls and comparable with outcomes expected in resource-rich settings. This study demonstrated the feasibility, safety, and efficacy of sqR-CHOP, increased the research infrastructure in Uganda, and will improve care in other resource-limited settings.
Authors
- Scott V. Adams (ORCID: https://orcid.org/0000-0002-8411-8051)
- Prossy Namuli
- Jackson Orem (ORCID: https://orcid.org/0000-0002-5366-9010)
- Joyce Kambugu (ORCID: https://orcid.org/0000-0003-2546-1068)
- Thomas S. Uldrick (ORCID: https://orcid.org/0000-0001-6959-0924)
- Henry Ddungu (ORCID: https://orcid.org/0000-0001-9227-4030)
- Kelvin Roland Mubiru (ORCID: https://orcid.org/0000-0001-8647-2399)
- Edus Houston Warren (ORCID: https://orcid.org/0000-0002-9570-2755)
- Andrea Towlerton (ORCID: https://orcid.org/0000-0002-7472-789X)
- Rosemary Namagembe (ORCID: https://orcid.org/0000-0002-6545-990X)
- Camille E. Puronen (ORCID: https://orcid.org/0000-0003-3340-360X)
- Jacqueline Asea
- Manoj Menon (ORCID: https://orcid.org/0000-0002-4981-0376)
Institutions
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Hutchinson Centre Research Institute in Uganda (UG)
- Uganda Cancer Institute (UG)
Publication Details
- Journal
- JCO Global Oncology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1200/go-24-00489
- Citations
- 2
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94