Neoadjuvant FOLF(IRIN)OX Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Multicenter Randomized Noncomparative Phase II Trial (PANACHE01 FRENCH08 PRODIGE48 study)
The feasibility and efficacy of mFOLFIRINOX in the perioperative setting are confirmed concerning therapeutic sequence completion and oncologic outcomes, supporting ongoing trials (PREOPANC3, Alliance AO21806). Further research is needed to identify patients who benefit from NAC (ClinicalTrials.gov identifier: NCT02959879; EudraCT: 2015-001851-65).
Authors
- Laëtitia Dahan (ORCID: https://orcid.org/0000-0001-5267-6190)
- Olivia Hentic
- Rim Chérif (ORCID: https://orcid.org/0000-0002-5686-5586)
- Guillaume Piessen (ORCID: https://orcid.org/0000-0001-8243-8310)
- Caroline Pétorin
- Jean‐Marc Regimbeau (ORCID: https://orcid.org/0000-0001-7631-9112)
- Julien Taı̈eb (ORCID: https://orcid.org/0000-0002-9955-4753)
- Laurent Sulpice (ORCID: https://orcid.org/0000-0002-8817-1685)
- Réza Kianmanesh (ORCID: https://orcid.org/0000-0001-5304-0602)
- Laurence Choné
- Ahmet Ayav (ORCID: https://orcid.org/0000-0001-8319-5664)
- C. Tournigand
- Eric Assénat (ORCID: https://orcid.org/0000-0002-8958-2793)
- Christophe Laurent (ORCID: https://orcid.org/0000-0003-2449-6349)
- Maximiliano Gelli (ORCID: https://orcid.org/0000-0001-9807-4021)
- Anthony Turpin (ORCID: https://orcid.org/0000-0002-2282-0101)
- David Tougeron (ORCID: https://orcid.org/0000-0002-8065-9635)
- Lilian Schwarz (ORCID: https://orcid.org/0000-0001-6726-8755)
- François Paye (ORCID: https://orcid.org/0000-0002-7193-2628)
- Olivıer Turrini (ORCID: https://orcid.org/0000-0002-2144-2380)
- Éveline Boucher (ORCID: https://orcid.org/0000-0002-3800-4192)
- Pierre Michel (ORCID: https://orcid.org/0000-0002-6442-2566)
- Jean‐Baptiste Bachet (ORCID: https://orcid.org/0000-0003-4337-286X)
- Célia Turco
- Jean‐Yves Mabrut (ORCID: https://orcid.org/0000-0002-5701-3588)
- Emmanuel Buc (ORCID: https://orcid.org/0000-0002-3559-166X)
- Stéphanie Truant (ORCID: https://orcid.org/0000-0002-2828-4864)
- Pascal Hammel (ORCID: https://orcid.org/0000-0002-4630-4996)
- Alain Sauvanet (ORCID: https://orcid.org/0000-0002-7436-5999)
- Emilia Ragot
- António Sá Cunha (ORCID: https://orcid.org/0000-0003-4015-5368)
- Karine Bouhier Leporrier
- Angélique Vienot (ORCID: https://orcid.org/0000-0002-0381-7601)
- Sébastien Gaujoux
- Mickaël Lesurtel (ORCID: https://orcid.org/0000-0003-2397-4599)
- Nicolas Tabchouri (ORCID: https://orcid.org/0000-0001-8591-6779)
- Éric Terrebonne
- Olivier Bouché (ORCID: https://orcid.org/0000-0002-8284-3743)
- Thierry André (ORCID: https://orcid.org/0000-0002-5103-7095)
- Vincent Moutardier
- Yann Touchefeu (ORCID: https://orcid.org/0000-0001-8421-3182)
- Thierry Lecomte (ORCID: https://orcid.org/0000-0001-5093-0212)
- Régis Souche (ORCID: https://orcid.org/0000-0002-1961-5844)
- David Fuks (ORCID: https://orcid.org/0000-0002-7827-1033)
- Romain Coriat (ORCID: https://orcid.org/0000-0003-4420-8340)
- Stéphane Benoist (ORCID: https://orcid.org/0000-0002-8087-7894)
- Nicolas Régenet
- Bruno Chauffert
- Emmanuel Mitry
- Jean-Pierre Richer
- Aurélia Meurisse
- C. Louvet
- Déwi Vernerey (ORCID: https://orcid.org/0000-0001-6399-926X)
- Jean‐Christophe Vaillant
- J. C. Souquet
- David Malka
- Jean Frédéric Blanc
- Jean Lubrano (ORCID: https://orcid.org/0000-0001-7163-0243)
- Fabienne Portales
- Anne Thiro-Bidault
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Aix-Marseille Université (FR)
- Université de Lille (FR)
- Université Paris-Saclay (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Sorbonne Université (FR)
- Centre Hospitalier Universitaire de Besançon (FR)
- Hôpital de la Croix-Rousse (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Methodology and Quality of Life Unit in Oncology (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Saint-Antoine (FR)
- Centre Hospitalier Universitaire de Reims (FR)
- Normandie Université (FR)
- Hôpital Cardiologique du Haut-Lévêque (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre de Recherche en Cancérologie de Lyon (FR)
- Hôpital Saint Eloi (FR)
- Institut Paoli-Calmettes (FR)
- Hôpital Claude Huriez (FR)
- Hôpital Paul-Brousse (FR)
- Université de Rouen Normandie (FR)
- Université de Reims Champagne-Ardenne (FR)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1200/jco-24-01378
- Citations
- 19
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 19.86