The Effect of Preexisting Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Infection Outcomes in Exposed Household Members
Our study suggests that prior SARS-CoV-2 antibodies provide some protection against Omicron BA.1/BA.2 infection, while effects on symptom burden or Ct value could not be demonstrated. The results highlight the relatively limited, but not negligible role of cross-protective antibodies, especially when facing immune escape variants of SARS-CoV-2.
Authors
- Marion Koopmans (ORCID: https://orcid.org/0000-0002-5204-2312)
- Patricia Bruijning‐Verhagen (ORCID: https://orcid.org/0000-0003-4105-9669)
- Reina S. Sikkema (ORCID: https://orcid.org/0000-0001-7331-6274)
- Ilse Westerhof (ORCID: https://orcid.org/0000-0001-7693-6137)
- Janko van Beek (ORCID: https://orcid.org/0000-0001-7463-9411)
- Ganna Rozhnova (ORCID: https://orcid.org/0000-0002-6725-7359)
Institutions
- University of Lisbon (PT)
- University of Applied Sciences Utrecht (NL)
- Utrecht University (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- National Institute for Public Health and the Environment (NL)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1093/infdis/jiaf172
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40