Stability and Accuracy of a Diagnosis of Parkinson Disease Over 10 Years
This study demonstrates significant diagnostic instability in PD, with 13.3% of diagnoses revised, primarily within 2 years. When DLB is considered separately, the revision rate increases to 17.7%. Despite frequent DAT imaging and limited postmortem examinations, clinical uncertainty persists among practicing neurologists, contrasting with lower misdiagnosis rates in specialized centers. These findings highlight the need for systematic application of diagnostic criteria, regular reevaluation of diagnoses, more frequent autopsies, and the development of accessible diagnostic biomarkers.
Authors
- Valtteri Räty (ORCID: https://orcid.org/0000-0002-6043-798X)
- Tero J. Vahlberg (ORCID: https://orcid.org/0000-0002-4935-3056)
- Joonas Majuri (ORCID: https://orcid.org/0000-0001-9144-2653)
- Tommi Noponen
- Marko Seppänen (ORCID: https://orcid.org/0000-0003-2106-9528)
- Valtteri Kaasinen (ORCID: https://orcid.org/0000-0002-3446-7093)
- Anna‐Maija Tolppanen (ORCID: https://orcid.org/0000-0001-9270-9268)
- Tomi Kuusimäki (ORCID: https://orcid.org/0000-0002-4829-7275)
- Maria Gardberg (ORCID: https://orcid.org/0000-0002-2179-4271)
Institutions
- University of Helsinki (FI)
- University of Turku (FI)
- University of Eastern Finland (FI)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1212/wnl.0000000000213499
- Citations
- 15
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 20.84