A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein
The Coronavirus Immunotherapeutic Consortium (CoVIC) conducted side-by-side comparisons of over 400 anti-SARS-CoV-2 spike therapeutic antibody candidates contributed by large and small companies as well as academic groups on multiple continents. Nine reference labs analyzed antibody features, including in vivo protection in a mouse model of infection, spike protein affinity, high-resolution epitope binning, ACE-2 binding blockage, structures, and neutralization of pseudovirus and authentic virus infection, to build a publicly accessible dataset in the database CoVIC-DB. High-throughput, high-resolution binning of CoVIC antibodies defines a broad and predictive landscape of antibody epitopes on the SARS-CoV-2 spike protein and identifies features associated with durable potency against multiple SARS-CoV-2 variants of concern and high in vivo efficacy. Results of the CoVIC studies provide a guide for selecting effective and durable antibody therapeutics and for immunogen design as well as providing a framework for rapid response to future viral disease outbreaks.
Authors
- Sivakumar Periasamy (ORCID: https://orcid.org/0000-0002-7038-5140)
- Michael L. Mallory (ORCID: https://orcid.org/0000-0003-0768-572X)
- Brendan Ha
- Anaïs Gambiez
- Paula A. Pino (ORCID: https://orcid.org/0000-0001-8626-926X)
- Matthew M Maddocks (ORCID: https://orcid.org/0000-0002-0189-0952)
- J. Park (ORCID: https://orcid.org/0000-0002-7510-0079)
- Alexander Bukreyev (ORCID: https://orcid.org/0000-0002-0342-4824)
- Ralph Steven Baric (ORCID: https://orcid.org/0000-0001-6827-8701)
- Elizabeth Feeney (ORCID: https://orcid.org/0000-0002-4513-8658)
- Bjoern Peters (ORCID: https://orcid.org/0000-0002-8457-6693)
- Luc Gagnon
- Jordi Bertran Torrelles (ORCID: https://orcid.org/0000-0001-7702-5941)
- Natalia A. Kuzmina (ORCID: https://orcid.org/0000-0001-6650-9369)
- S. Khan (ORCID: https://orcid.org/0000-0002-6578-8471)
- Georgia D. Tomaras (ORCID: https://orcid.org/0000-0001-8076-1931)
- Haoyang Li (ORCID: https://orcid.org/0000-0003-3024-1350)
- Jarjapu Mahita
- Gillian Q. Horn (ORCID: https://orcid.org/0000-0003-4571-1933)
- Sharon L. Schendel (ORCID: https://orcid.org/0000-0002-5062-7261)
- Richard H.C. Huntwork (ORCID: https://orcid.org/0000-0002-9650-1154)
- Mary Osei-Twum
- Daniel Bedinger (ORCID: https://orcid.org/0000-0001-5009-9369)
- Amberlee Hicks
- Jennifer E. Munt (ORCID: https://orcid.org/0000-0002-1169-025X)
- Luis Martínez‐Sobrido (ORCID: https://orcid.org/0000-0001-7084-0804)
- Paul Kellam (ORCID: https://orcid.org/0000-0003-3166-4734)
- Erica Ollmann Saphire (ORCID: https://orcid.org/0000-0002-1206-7451)
- Stephen T. Reece (ORCID: https://orcid.org/0000-0003-0725-6271)
- Heather Callaway (ORCID: https://orcid.org/0000-0003-4003-3854)
- Peter Halfmann (ORCID: https://orcid.org/0000-0002-1648-1625)
- Marie-Noelle Lepage
- Yoshihiro Kawaoka (ORCID: https://orcid.org/0000-0001-5061-8296)
- Xiaoying Yu (ORCID: https://orcid.org/0000-0003-1659-2365)
- Natalie St-Amant
- Kathryn M. Hastie (ORCID: https://orcid.org/0000-0002-3406-1210)
- Trevor Scobey (ORCID: https://orcid.org/0000-0001-8313-5434)
- Anne Palser (ORCID: https://orcid.org/0000-0002-9476-8808)
- Camille Troup
- Milite Abraha (ORCID: https://orcid.org/0000-0001-7668-4320)
- Kan Li (ORCID: https://orcid.org/0009-0004-0582-3863)
- Timothy Germann (ORCID: https://orcid.org/0000-0001-8128-361X)
- Chengjin Ye (ORCID: https://orcid.org/0000-0002-1934-9494)
- S. Moses Dennison
- Billie Maingot
Institutions
- University of North Carolina at Chapel Hill (US)
- Texas Biomedical Research Institute (US)
- La Jolla Institute for Immunology (US)
- University of Wisconsin–Madison (US)
- Texas A&M University at Galveston (US)
- Duke University (US)
- Nexen (Canada) (CA)
- Galveston College (US)
- Biotechnology Research Center (IR)
- Carterra (United States) (US)
- National Center for Global Health and Medicine (JP)
- Kymab (United Kingdom) (GB)
- Imperial College London (GB)
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Cell Reports
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.celrep.2025.115499
- Citations
- 4
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 5.58