Effect of Triphalakatakanpathadi Kashaya on glycaemic control and quality of life in type 2 diabetes mellitus in Sri Lankan population – A descriptive observational study

Diabetes mellitus (DM) presents a significant global health burden, often leading to complications and reduced quality of life. Ayurveda, a traditional system of medicine practiced globally, often uses Kashaya (herbal decoctions) for the management of diabetes. This article aims to assess the effect of Triphalakatakanpathadi Kashaya (TKPK) on glycemic control and quality of life in patients with type 2 diabetes . A descriptive observational study was conducted involving 46 patients treated with TKPK for six months at Bandaranaike Memorial Ayurveda Research Institute (BMARI), Sri Lanka. Data on glycemic parameters, diabetes related signs and symptoms , and quality of life using the short form of quality of life questionnaire (SF-36) were collected and analyzed using paired t-test, and Wilcoxon signed rank test. TKPK led to significant reduction in mean baseline value of HbAIc from 7.11% to 6.58% ( p < 0.05) and mean baseline fasting blood sugar level from 172.4 ± 6.03 mg/dl to 141.4±4.99 mg/dl ( p < 0.05) after six months. Significant improvements ( p < 0.05) were observed in diabetes related signs and symptoms. Transaminases (AST & ALT) and serum creatinine levels remained within normal ranges throughout the study period reflecting the safety of TKPK. Quality of life was enhanced significantly ( p < 0.05) in all the patients. TKPK demonstrates the efficacy to lower blood glucose and improve the quality of life in type 2 DM patients. Scientific evidence of TKPK’s ingredients, suggest anti-inflammatory and anti-oxidant properties as contributing factors for its hypoglycemic effect. However, observational study imposes limitations, and warrant further clinical trials to establish the efficacy of this formulation.