YAP1 activates SLC2A1 transcription and augments the malignant behavior of colorectal cancer cells by activating the Wnt/β-catenin signaling pathway
SLC2A1 is critical in CRC progression, with YAP1 serving as a key regulator of its expression and function. The YAP1-SLC2A1-Wnt axis represents a potential therapeutic target for CRC, providing insights into metabolic adaptations that support tumor growth and metastasis.
Authors
- Yutian Dai (ORCID: https://orcid.org/0000-0002-1459-8934)
- Zhigang Zhang
- Haifeng Zhang (ORCID: https://orcid.org/0000-0002-7963-9071)
- Kunpeng Li (ORCID: https://orcid.org/0000-0003-1807-4545)
Institutions
- Zhongda Hospital Southeast University (CN)
Publication Details
- Journal
- Cell Division
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s13008-025-00148-y
- Citations
- 5
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03