FHL2 deteriorates IL-1β induced inflammation, apoptosis, and extracellular matrix degradation in chondrocyte-like ATDC5 cells by mTOR and NF-ĸB pathways
FHL2 knockdown activated autophagy while suppressing inflammation, apoptosis, and ECM degradation. The mechanism underlying these processes may involve the inhibition of the mTOR and NF-ĸB signaling pathways.
Authors
- Yicheng Li
- Baochao Ji (ORCID: https://orcid.org/0000-0001-6136-2206)
- Fei Wang (ORCID: https://orcid.org/0000-0001-7086-1840)
- Li Cao (ORCID: https://orcid.org/0000-0002-0156-4081)
- A. Amati
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s12891-025-08536-9
- Citations
- 1
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China