Ginger extract inhibits c-MET activation and suppresses osteosarcoma in vitro and in vivo
Collectively, our findings show that c-MET is a prospective therapeutic target for OS. Ginger extract, a natural c-MET inhibitor, exhibits potent antineoplastic effects by suppressing OS growth both in vitro and in vivo, highlighting its prospect for a new therapeutic agent of this aggressive malignancy.
Authors
- Junyan Teng
- Siyuan Han (ORCID: https://orcid.org/0000-0001-8419-1331)
- Mingyang Yan
- Tao Li (ORCID: https://orcid.org/0000-0001-7461-5575)
- Yu Yin (ORCID: https://orcid.org/0000-0001-6040-6115)
- Huijun Zhang (ORCID: https://orcid.org/0000-0003-1722-7511)
- Xiangping Li (ORCID: https://orcid.org/0000-0002-0238-3557)
- Hao Li (ORCID: https://orcid.org/0000-0002-1703-3760)
- Ziliang Zhang (ORCID: https://orcid.org/0000-0001-9981-8598)
- Zhiping Guo (ORCID: https://orcid.org/0000-0003-0454-1149)
- Ruoping Yanzhang
- Xiao Chu
- Guoguo Jin
- Zhaojie Yang
- Ruifang Shen
Institutions
- Zhengzhou University (CN)
- China-US (Henan) Hormel Cancer Institute (CN)
- Zhengzhou Central Hospital (CN)
- Luoyang Orthopedic-Traumatological Hospital of Henan Province (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s12935-025-03759-1
- Citations
- 4
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 6.23
Funders
- National Natural Science Foundation of China
- Henan Provincial Science and Technology Research Project