Abnormal activity in the brainstem affects gait in a neuromusculoskeletal model
Our results indicate that pedunculopontine nucleus and cuneiform nucleus activities could be linked with freezing of gait and that different modifications of those activities could generate observed freezing of gait subtypes. Our models can provide insights relevant for understanding the pathophysiological mechanisms of freezing of gait and are expected to assist in the classification of freezing of gait subtypes.
Authors
- Daisuke Ichimura (ORCID: https://orcid.org/0000-0002-5170-6420)
- Ritsuko Hanajima
- Kenji Wada (ORCID: https://orcid.org/0000-0002-2178-7522)
- Makoto Sawada (ORCID: https://orcid.org/0000-0003-4143-5791)
Institutions
- Kawasaki Medical School (JP)
- Tottori University (JP)
Publication Details
- Journal
- Journal of NeuroEngineering and Rehabilitation
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s12984-025-01596-x
- Primary Topic
- Cerebral Palsy and Movement Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Advanced Industrial Science and Technology
- New Energy and Industrial Technology Development Organization
- Council for Science, Technology and Innovation
- Japan Society for the Promotion of Science