A Cascade Cyclization of Orthogonally Protected Diaminodiazoketones to Sp<sup>3</sup>‐Enriched Fused 1,2,3‐Triazoles
Abstract A convenient approach to the synthesis of sp 3 ‐enriched bicyclic 1,2,3‐triazole derivatives based on the cascade cyclization of diaminodiazoketones with orthogonal protecting groups has been developed. The method is based on available commercial starting compounds and simple, environmentally acceptable synthesis methods. The formation of a condensed 1,2,3‐triazole ring is accompanied by the loss of chirality of the carbon atom near Boc‐amino group.
Authors
- Hanna Yakovleva (ORCID: https://orcid.org/0009-0001-3718-7708)
- Dmitriy M. Volochnyuk (ORCID: https://orcid.org/0000-0001-6519-1467)
- Serhii Bohza (ORCID: https://orcid.org/0000-0002-1274-3720)
- Svitlana V. Shishkina (ORCID: https://orcid.org/0000-0002-3946-1061)
- Viacheslav Pendiukh (ORCID: https://orcid.org/0009-0003-7623-6028)
- Oleg Svaljavin (ORCID: https://orcid.org/0009-0004-0692-691X)
Institutions
- State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine (UA)
- Institute of Organic Chemistry (UA)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/slct.202406027
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Academy of Sciences of Ukraine