Evaluating the diagnostic performance of six plasma biomarkers for Alzheimer’s disease and other neurodegenerative dementias in a large Chinese cohort
This study validate the practicality of blood biomarkers in the Chinese Han population using a novel single molecule immune detection method. Through the clinical performance study for several biomarkers, we found the plasma p-tau217 was the most effective biomarker in AD diagnosis, and p-tau showed high accuracy for differential diagnosis of AD from other dementia, GFAP is associated with multiple aspects of AD pathology, and frontal and temporal lobe volume, and p-tau181 can reflect the dynamic cognitive decline of AD.
Authors
- Meidan Wan
- Xuewen Xiao
- Ziyu Ouyang
- Xinxin Liao (ORCID: https://orcid.org/0000-0003-1461-900X)
- Bin Jiao (ORCID: https://orcid.org/0000-0002-6337-0784)
- Tianyan Xu
- Yuan Zhu (ORCID: https://orcid.org/0000-0002-0327-9727)
- Shilin Luo
- Yiliang Liu (ORCID: https://orcid.org/0000-0001-7703-7512)
- Beisha Tang (ORCID: https://orcid.org/0000-0003-2120-1576)
- Cong Zhang (ORCID: https://orcid.org/0000-0002-6874-495X)
- Weiwei Zhang
- Yafang Zhou (ORCID: https://orcid.org/0000-0002-1689-4462)
- Lu Shen (ORCID: https://orcid.org/0000-0001-5237-6155)
- Xixi Liu (ORCID: https://orcid.org/0000-0003-1992-5970)
- Sizhe Zhang (ORCID: https://orcid.org/0000-0003-4691-9779)
- Qijie Yang
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1186/s13195-025-01712-y
- Citations
- 10
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 11.64
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province