Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion
Malignant pleural effusion (MPE), persistently generated by thorax tumor cells at the advanced stage, remains a major challenge for cancer therapy. Herein, we develop an ultra-sensitive piezoelectric nano-system by doping ytterbium in metal-organic framework (O<sub>3</sub>P@LPYU), which can be triggered by physiological intrapleural pressure during breath. Under the gently alterative pressure, the piezoelectric nanoparticles with notable peroxidase-like activity effectively produce a burst of reactive oxygen species and induce immunogenic cell death by catalysis of carried ozone as well as peroxide in interstitial fluid. A clear and sustained biodistribution is observed in thorax effusion and tumors upon intrapleural administration of particle. Remarkably, due to the abundant substrates in oxygen-rich environment of pleural cavity, O<sub>3</sub>P@LPYU particle provides a potent reduction of MPE volume and durable inhibition of tumor growth in thorax. Our work not only develops a bio-responsive piezoelectric nano-system, but also provides a strategy for persistent suppression of MPE in clinics.
Authors
- Tianyue Xu
- Xiujing He (ORCID: https://orcid.org/0000-0002-6161-1679)
- Peixin Du
- Zihan Xu (ORCID: https://orcid.org/0000-0002-5632-0439)
- Wei Zhuo (ORCID: https://orcid.org/0000-0002-8251-4210)
- Meixu Chen (ORCID: https://orcid.org/0000-0003-2712-5551)
- Lingkai Tang (ORCID: https://orcid.org/0000-0001-9861-7436)
- Hubing Shi (ORCID: https://orcid.org/0000-0002-2926-3440)
- Yong Luo (ORCID: https://orcid.org/0000-0002-7150-552X)
- Xin Wang (ORCID: https://orcid.org/0000-0001-5192-8093)
- Linlin Song
- Yuxin Zhao
- Huan Meng (ORCID: https://orcid.org/0000-0001-8844-3938)
- Siyi Chen (ORCID: https://orcid.org/0000-0002-8812-8855)
- Yu Gui (ORCID: https://orcid.org/0000-0001-6438-1170)
- Jianping Hu (ORCID: https://orcid.org/0000-0001-9941-1616)
- Yujie Zhao (ORCID: https://orcid.org/0000-0002-6702-6526)
- Feng Luo (ORCID: https://orcid.org/0009-0006-9343-0721)
- Jing Jing (ORCID: https://orcid.org/0000-0003-0033-9736)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Third People's Hospital of Chengdu (CN)
- Chengdu University (CN)
- National Center for Nanoscience and Technology (CN)
- Ministry of Education (KN)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1038/s41467-025-58354-9
- Citations
- 5
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 3.37