SOX4 accelerates intervertebral disc degeneration via EZH2/NRF2 pathway in response to mitochondrial ROS-dependent NLRP3 inflammasome activation in nucleus pulposus cells
Our findings suggest that SOX4 accelerates IDD progression by promoting NLRP3 inflammasome activation via modulating the EZH2/NRF2 pathway, leading to NP cell pyroptosis and ECM degradation. Targeting SOX4 may represent a potential therapeutic strategy for treating IDD.
Authors
- Guiqi Zhang
- Yunxiang Hu (ORCID: https://orcid.org/0000-0001-6331-5809)
- Wenzhi Zhao (ORCID: https://orcid.org/0000-0002-3125-2310)
- Yadong Liu (ORCID: https://orcid.org/0000-0003-3636-9523)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Dalian Municipal Central Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1186/s12967-024-05913-1
- Citations
- 7
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 10.30