Mn(III) catalyzed cascade cross-coupling / annulation / C(O)-C bond insertion / rearrangement: Access to multi-substituted indolenines in water

This study presents an Mn-catalyzed method for the synthesis of multi-substituted indolenines via a cascade process in one-pot reaction which is conducted in water. The catalyst's efficiency, as low as 5 ​mol%, is significantly enhanced by the addition of Zn 2 (OH) 2 CO 3 . A wide array of functional groups is tolerated, and this method introduces bioactive molecules into the indolenine structures. Additionally, gram-scale experiments give comparable results to smaller-scale studies, demonstrating its practical application in late-stage functionalization.