TRAF7 knockdown induces cellular senescence and synergizes with lomustine to inhibit glioma progression and recurrence
TRAF7 could be used as a predictive biomarker and the potential therapeutic target among National Comprehensive Cancer Network (NCCN) treatment guidelines in the progression and recurrence of glioma. Lomustine, regulating cellular senescence and cell cycle could be the priority choice in glioma patients with high-level TRAF7 expression.
Authors
- Bin Zhong
- Peihao Hu
- Dong-Cheng Xu
- Rongrong Zhou (ORCID: https://orcid.org/0000-0003-4483-0615)
- Tongyu Zhou (ORCID: https://orcid.org/0000-0001-5486-7214)
- Yuxin Zhao (ORCID: https://orcid.org/0000-0003-1776-4173)
- Jing Di (ORCID: https://orcid.org/0000-0001-5637-8748)
- Wen Ce Sun (ORCID: https://orcid.org/0000-0003-4316-5350)
- Juncheng Yao
- Yu Chen (ORCID: https://orcid.org/0000-0002-8206-3325)
- Yan Li (ORCID: https://orcid.org/0000-0001-7685-6073)
- Yumeng Zhang (ORCID: https://orcid.org/0009-0008-0167-4708)
- Jingrui Liang (ORCID: https://orcid.org/0000-0002-3952-6339)
- Qiyi Zhou
Institutions
- Central South University (CN)
- King's College London (GB)
- Dalian Medical University (CN)
- Soochow University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- National Vaccine and Serum Institute (CN)
- Ministry of Agriculture (HU)
- Ministry of Agriculture (ID)
- Second Affiliated Hospital of Soochow University (CN)
- Yueyang Hospital (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s13046-025-03363-1
- Citations
- 6
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- Natural Science Foundation of Hunan Province