Genomic prediction with kinship-based multiple kernel learning produces hypothesis on the underlying inheritance mechanisms of phenotypic traits
We show that GMKL performs similarly to GBLUP, but it can formulate biological hypotheses about inheritance mechanisms, such as suggesting that epistasis influences IBD.
Authors
- Daniele Raimondi (ORCID: https://orcid.org/0000-0003-1157-1899)
- Antoine Passemiers (ORCID: https://orcid.org/0000-0002-9492-7311)
- Yves Moreau (ORCID: https://orcid.org/0000-0002-4647-6560)
- Deborah Sarah Jans (ORCID: https://orcid.org/0000-0003-2791-2010)
- Nora Verplaetse (ORCID: https://orcid.org/0000-0002-2341-5423)
- Isabelle Cleynen (ORCID: https://orcid.org/0000-0003-0857-7683)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Center for Human Genetics (US)
- Institut de Génétique Moléculaire de Montpellier (FR)
- KU Leuven (BE)
Publication Details
- Journal
- Genome biology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s13059-025-03544-3
- Primary Topic
- Genetic and phenotypic traits in livestock
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek