Twelve-month efficacy of carboxymethyl-chitosan in refractory knee osteoarthritis: A randomized controlled trial (PIONEER)
In this difficult-to-treat population, CM-chitosan was non-inferior to Hylan G-F 20, but did show clinically important, though not statistically significant, differences in pain reduction at 12 months. CM-chitosan was effective in improving OA symptoms and physical function for 12 months.
Authors
- Philippe Van Overschelde
- Pieter Vansintjan
- Mickaël Chausson (ORCID: https://orcid.org/0000-0002-2333-8085)
- Wim Weyenberg
- Nicolas Portelange
Institutions
- AZ Maria Middelares (BE)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100605
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.34