PD-1 suppression enhances HIV reactivation and T-cell immunity via MAPK/NF-κB signaling
PD-1 mediates HIV immune evasion through the MAPK/NF-κB pathways. PD-1 blockade restores T-cell function and activates latent HIV, suggesting potential therapeutic strategies for HIV treatment.
Authors
- Bo Song (ORCID: https://orcid.org/0000-0002-0161-1052)
- Xueru Lin (ORCID: https://orcid.org/0000-0002-9928-153X)
- Jun‐Li Cao (ORCID: https://orcid.org/0000-0002-8932-4743)
- Siyu Liu (ORCID: https://orcid.org/0000-0003-0959-4071)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-0018-3903)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Xue Wang (ORCID: https://orcid.org/0009-0009-3062-2103)
- Shuchen Li (ORCID: https://orcid.org/0000-0001-5620-5054)
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s40001-025-02427-4
- Citations
- 7
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.25