Associations between cardiometabolic indices and the onset of metabolic dysfunction-associated steatotic liver disease as well as its progression to liver fibrosis: a cohort study
The risk of developing MASLD increases as the level of cardiometabolic indices increases. Obesity may serve as a mediating factor in the aforementioned association. TyG-BMI showed the strongest association with the onset of MASLD and its progression to liver fibrosis, proved to be outperformed other cardiometabolic indicators, and could be the best clinical non-invasive biomarker for early screening of MASLD and liver fibrosis.
Authors
- Yuting Sun (ORCID: https://orcid.org/0009-0005-5236-4660)
- Ziping Song (ORCID: https://orcid.org/0009-0005-1250-7575)
- Xinlei Miao (ORCID: https://orcid.org/0000-0001-8539-6451)
- Xiaoling Xie (ORCID: https://orcid.org/0000-0002-0092-900X)
- Song Leng (ORCID: https://orcid.org/0000-0001-6692-9195)
- Manling Hu (ORCID: https://orcid.org/0009-0000-9424-3385)
- Shuang Liu (ORCID: https://orcid.org/0009-0001-4284-7897)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1186/s12933-025-02716-6
- Citations
- 13
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 17.60
Funders
- Dalian Medical University