Novel eudesmanolides from the flowers of <i>Pentanema britannicum</i> (L.) D.Gut.Larr with antidepressant activities
From the flowers of <i>Pentanema britannicum</i> (L.) D.Gut.Larr., three new eudesmanolides, britannitin A (<b>1</b>), britannitin B (<b>2</b>) and britannitin C (<b>3</b>), as well as 17 known compounds, were successfully extracted. Compounds <b>1</b>-<b>3</b> were eudesmane sesquiterpene lactones with a rare -C = C- linking carbons 7 and 11. Structural determination of the separated compounds was achieved through a range of spectroscopic techniques, such as 1D and 2D NMR analyses. Compound 5<i>β</i>-hydroxyasperilin (<b>HA</b>) demonstrated the ability to ameliorate depression-like behaviours in mice induced by CSDS, suggesting its potential antidepressant effect.
Authors
- Yu‐Cheng Gu (ORCID: https://orcid.org/0000-0002-6400-6167)
- Yan Fu (ORCID: https://orcid.org/0000-0002-4942-159X)
- Yu-Qing Xie
- Junhui Zhang (ORCID: https://orcid.org/0000-0003-4199-4884)
- Ping He (ORCID: https://orcid.org/0000-0002-3871-8128)
- Jian Su
- Xinyue Zhang (ORCID: https://orcid.org/0000-0003-2486-1107)
- Yang Song (ORCID: https://orcid.org/0000-0002-4702-8962)
- Yibing Wu (ORCID: https://orcid.org/0000-0003-4168-0295)
- Zhi‐Yu Ni (ORCID: https://orcid.org/0000-0003-1818-6125)
Institutions
- Hebei University of Engineering (CN)
- Hebei Medical University (CN)
- Affiliated Hospital of Hebei University (CN)
- Syngenta (Switzerland) (CH)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1080/14786419.2025.2487683
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China