Hyphal penetration is the major pathway of translocation of Candida albicans across the blood-cerebrospinal fluid barrier
Our findings reveal that Candida albicans can use transcellular translocation to invade into the CNS and is able to circumvent major host immune response, which may impact on diagnostic and preventive strategies.
Authors
- Thomas Lehrnbecher (ORCID: https://orcid.org/0000-0002-6022-3439)
- Ralf Schubert (ORCID: https://orcid.org/0000-0002-7124-0904)
- Christian Schwerk (ORCID: https://orcid.org/0000-0002-1706-0259)
- Hiroshi Ishikawa (ORCID: https://orcid.org/0000-0001-6310-5748)
- Horst Schroten (ORCID: https://orcid.org/0000-0001-8556-0995)
- Stanislaw Schmidt
- H. Rudolph
Institutions
- Goethe University Frankfurt (DE)
- University of Tsukuba (JP)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s12987-025-00644-x
- Citations
- 1
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Hilfe für krebskranke Kinder Frankfurt
- Bundesministerium für Bildung und Forschung