Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus
In conclusion, our study suggests that the newly synthesized Co-29 may serve as a potential antiviral candidate or lead compound for future studies.
Authors
- Leonard Krall (ORCID: https://orcid.org/0009-0008-6211-8174)
- Chunyan Wu (ORCID: https://orcid.org/0000-0003-3192-3126)
- Xianglan Liu (ORCID: https://orcid.org/0000-0001-8870-8174)
- Qingfeng Chen (ORCID: https://orcid.org/0000-0001-9526-0806)
- Jiarui Wu (ORCID: https://orcid.org/0000-0002-1617-6110)
- Jiaming Hu (ORCID: https://orcid.org/0000-0001-5028-3123)
- Yiru Tian
- Jinbo Wang (ORCID: https://orcid.org/0000-0002-7924-0781)
- Qun Lu (ORCID: https://orcid.org/0000-0003-3761-4236)
- Yan‐Ping He
Institutions
- Yunnan University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southern University of Science and Technology (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s12985-025-02687-w
- Citations
- 2
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Natural Science Foundation of China
- Yunnan University