Mediators of the causal associations between protein ratios and ischemic stroke: a two-step Mendelian randomization study
Our MR study combined with co-localization analysis identifies causal links between protein interactions and IS, highlighting potential targets to disrupt pathways connecting protein ratio changes to IS incidence and outcomes, offering promising intervention avenues.
Authors
- Fangfang Li (ORCID: https://orcid.org/0009-0004-4145-1307)
- Hao Chen (ORCID: https://orcid.org/0000-0003-0393-723X)
- Huaming Tan (ORCID: https://orcid.org/0009-0007-5175-9833)
- Han Yan (ORCID: https://orcid.org/0000-0003-2789-0798)
- Feng Qian (ORCID: https://orcid.org/0000-0002-4752-0770)
- Yang Yao (ORCID: https://orcid.org/0009-0005-7896-2204)
- Ying Li (ORCID: https://orcid.org/0009-0002-2891-9863)
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1080/01616412.2025.2487867
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Priority Academic Program Development of Jiangsu Higher Education Institutions