Pilot Randomized Trial Exploring the Impacts of Deceased Donor Kidney Procurement Biopsies on Organ Evaluation and Transplant Outcomes
This pilot RCT did not suggest concerns for delayed DD kidney biopsy information on organ use or transplant outcomes. However, the randomized sample was small, underpowered, and comprised intermediate-risk donors. Trial conduct required considerable effort and faced a high disenrollment rate. Substantial expansion would be required to detect clinically significant differences in outcomes in future trials. Building evidence on the role of kidney procurement biopsies may require national collaboration and consideration of <i>opt-out</i> consent models for waiting candidates.
Authors
- Krista L. Lentine (ORCID: https://orcid.org/0000-0002-9423-4849)
- Vidyaratna Fleetwood (ORCID: https://orcid.org/0000-0002-7655-9375)
- Diane Brockmeier (ORCID: https://orcid.org/0000-0003-4949-3451)
- Henry B. Randall (ORCID: https://orcid.org/0000-0003-4075-2605)
- Richard Rothweiler
- Tiffany Caza
- Craig Dedert
- Melissa Lichtenberger
- Gary F. Marklin (ORCID: https://orcid.org/0000-0003-2920-4835)
- Mark A. Schnitzler (ORCID: https://orcid.org/0000-0001-8547-5643)
- Yaşar Çalışkan (ORCID: https://orcid.org/0000-0003-3816-8047)
- Jason R. Wellen
- Huiling Xiao
- Yoon Son Ahn
Institutions
- Washington University in St. Louis (US)
- Saint Louis University Hospital (US)
- Arkana Laboratories (US)
- Hennepin Healthcare Research Institute (US)
- Association of Organ Procurement Organizations (US)
- Saint Louis University (US)
Publication Details
- Journal
- Cureus
- Published
- 2025-04-04
- DOI
- https://doi.org/10.7759/cureus.81728
- Citations
- 1
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.99
Funders
- Saint Louis University