Cognitive Phenotyping and Interpretation of Alzheimer Blood Biomarkers

Results from 2 clinical cohorts suggest that amyloid prevalence varied across cognitive phenotypes and was associated with the diagnostic performance of blood p-tau217 models to determine brain amyloidosis. Comprehensive cognitive phenotyping beyond the basic characterization of SCI, MCI, or dementia should accompany the use of blood biomarkers in clinical practice to avoid misdiagnosis due to false positives.

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Publication Details

Journal
JAMA Neurology
Published
2025-04-05
DOI
https://doi.org/10.1001/jamaneurol.2025.0142
Citations
15
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
22.07

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article

Cognitive Phenotyping and Interpretation of Alzheimer Blood Biomarkers

Rémy Guillevin, Nathanaëlle Yeni, M. Rodallec, Amandine Pallardy et al.
15 citations
JAMA Neurology
Dementia and Cognitive Impairment Research
22.07
article

Cognitive Phenotyping and Interpretation of Alzheimer Blood Biomarkers

Rémy Guillevin, Nathanaëlle Yeni, M. Rodallec, Amandine Pallardy, Guillaume Sacco, Mathieu Tafani, Éléna Paillaud, Inna Dygai‐Cochet, Xavier De Petigny, Jean‐Yves Gaubert, Lisa Le Scouarnec, Sandrine Harston, Pierre Vandel, Karl Mondon, François Cotton, Olivier Beauchet, Françoise Lala, Franck Lacœuille, Anne-Marie Schneider, Thierry Dantoine, Cristiano Santos, Leslie Grasset, Cathérine Belin, Olivier Hanon, N Charász, F. Labourée, Isabelle Rouch, Benjamin Crétin, Jacques Boddaert, Jean‐Philippe Cottier, Julie Erraud, Giovanni Castelnovo, Michèle Puel, Éloi Magnin, Christian Scheiber, Marie‐Neige Videau, Susanna Schraen‐Maschke, Yann Spivac, Nathalie Philippi, Isabelle Defouilloy, Caroline Grangeon, Laure Koch Caillard, V. Moullart, François Salmon, Jean‐Luc Novella, Laure Joly, Marie Laurent, Catherine Faisant, Laïla Bouzid, Olivier Martinaud, Olivier Félician, Audrey Gabelle, Bernadette Allinquant, Olivier Couturier, Thierry Voisin, Keren Danaila, Pierre‐Yves Brillet, Evelyne Galbrun, Frédéric Bloch, Christophe Bouvier, Isabelle Marcet, Olivier Bailon, G. Petyt, C. Gallazzini-Crépin, Sylvain Lehmann, David Wallon, Emmanuel Cognat, R. Perdrisot, Emmanuelle Duron, Thomas Desmidt, Anne‐Cécile Troussière, M. Décousus, Pierre‐Yves Salaün, Diane Dupuy, Sophie Mohr, Mira Didic, Fabienne Giraud, A. Kelly, Hervé Deramond, Nicolas Villain, Nathalie Sastre, Valérie Chauviré, Alain Sarciron, Yasmina Boudali, Fernando González‐Ortiz, Samuel David, Jacques Hugon, Patrice Douillet, I. Couret, Pascaline Cassagnaud, Nadine Girard, Helen Savarieau, Nathalie Thierry, Zaza Makaroff, Didier Hannequin, Philippe Fernandez, Serge Bracard, H. Lenoir, Ana-Maria Dăscaliţa, Denis Fédérico, Jean‐Marc Constans, Olivier Godefroy, Guillaume Nivaggioni, Caroline Hommet, Chantale Dumoulin, Alexandre Augier, Nathalie Schwald, Guillaume Bertrand, D. Ben Salem, Isabelle Merlet, Agnès Devendeville, Micheline Razzouk‐Cadet, Claire Thalamas, Jean‐Claude Getenet, Olivier Vercruysse, C. Roubaud, Gabriel Pop, Galdric Orvoën, Pierre Payoux, P. Viau, C. Adam, V. Cressot, Sylvie Pariel, Matthieu Plichart, J.Y. Tanguy, Claude Guériot, Stéphanie Roseng, Aurélie Mouton, S. Querellou, I. Migeon-Duballet, Monique Galitzky, Jean‐Sébastien Vidal, Alexandra Foubert‐Samier, Clément Morgat, François Bertin‐Hugault, Edouard Chaussade, Chabha Azouani, Cyrille P. Launay, Chloé Rachez, Julien Dumurgier, John Avet, Philippe Robert, Lisette Volpe‐Gillot, Muriel Quillard‐Muraine, Isabelle Bourdel‐Marchasson, Valérie Boilet, Émilie Laheranne, Julie Roux, Hélène Sordet‐Guépet, Stéphane Kremer, Carole Dufouil, Isabelle Addra, Marc Berger, Alexandre Krainik, Christiane Baret‐Rose, Catherine Terrat, Marc Teichmann, Sarah Benisty, G. Pinganaud, Isabelle Pellegrin, Guila Abitbol, Djamila Krabchi, Nathalie Wagemann, Michel Nonent, Karim Bennys, Nicolas Auguste, Izzie Jacques Namer, Joanne Jenn, Antoine Brangier, Marie‐Anne Mackowiak, C. Moussard, Joël Belmin, Yves Rolland, Sophie Pichierri, Thérèse Jonveaux, Serge Belliard, Renaud David, Sophie Haffen, Daniel Fagret, J Zinszner, François Sellal, Delphine De Verbizier-Lonjon, Stéphanie Bombois, Léna Kermanac’h, F. Cattin, Anna Kearney‐Schwartz, Adeline Rollin‐Sillaire, Alain Carpentier, Agnès Camus, Hugo Bertin, Valérie Gissot, Candice Picard, Vincent Planche, Bertille Périn, Olivier Guérin, Vincent Deramecourt, Chantal Lamy, Geneviève Chêne, Fabienne Calvas, G. Béra, Pascale Cowppli-Bony, F. Latour, Pierre Anthony, Jean Laplanche, Emmanuel Gerardin, Olivier Rouaud, A. Pasco, Xavier Delbeuck, Daniel Grucker, Michaël Taroux, Nathalie Keromnes, Samia Belkacem, Pacôme Fosse, Julien Detour, Athanase Bénétos, Catherine Bayle, Sophie Pérusat, Clémence Boully, Amélie Serra, Laurence Hugonot-Diener, Athina Marantidou, Antoine Verger, Fati Nourhashémi, Olivier Marcy, Vincent Bouteloup, Sophie Chauvelier, F. Hubelé, Céline Guillemaud, Idil Yuksekel, Claire Boutet, Betty Jean, Maxime Locatelli, Florence Moulin, Mathieu Queneau, Fabrice-Guy Barral, Lora Cohen, Marie‐Thérèse Rabus, Agnès Jacquin-Piques, María Soto, Franck Semah, Delphine Dubail, Agnès Michon, Nathalie Sastre‐Hengan, Claire Gervais, Mohamed Abdellaoui, Samia Cheriet, Jean-François Mangin, Maritchu Doireau, Laure Ducroq-Ducastaing, Isabelle Franck, Radka Gantchev, Laurence Garbarg-Chenon, Stéphanie Libercier, Aïcha Medjoul, Georges Niewiadomski, Marie Noblet, Hélène Robin-Ismer, Aziza Waissi-Sediq, Emilie Bergouin, Catherine Beze, Hatem Bouhladour, Catherine Demuyinck, Anthony Clotagatide, Pierre-Yves Pare, Sandrine Andrieu, Guillaume Gautier, Jacques Touchon, Aurélie Kas, Vincent Camus, Jacques Darcourt, Frédérique Etcharry‐Bouyx, Hélène Oesterle, Éric Berger, Mathilde Sauvée, Ludivine Chamard, Bruno Vellas, Claire Paquet, Eric Guedj, Marie Chupin A, Marie‐Anne Mackowiak‐Cordoliani, Sophie Auriacombe, Yves Guilhermet, Antonio Dos Santos, Gilles Berrut, Catherine Martin‐Hunyadi, Jamila Thabet, S. Chanalet, Marc Paccalin, Alain Bonafé, Marie-Agnès Picat, Karim Farid, Jean-François Dartigues, Danielle Mestas, Jean Barré, Marc-Étienne Meyer, Stéphane Lehéricy, Sullivan Marie, Lejla Koric, Marie Odile Habert, Eliana Alonso, Martine Vercelletto, Véronique Eder, Michel Zanca, Christine Delmaire, Maria-João Santiago-Ribeiro, Julien Delrieu, Christine Astier, Cécilia Marelli, Kaj Blennow, Marion Paulin, Pierre Véra, Catherine Thomas-Antérion, Anne‐Sophie Rigaud, Marie‐Laure Seux, Jean‐Philippe David, Idalie Martin, Sandrine Canaple, Christine Perret‐Guillaume, Isabelle Saulnier, Pierre-Jean Ousset, Mathieu Chastan, Marcel Lévy, Anna‐Chloé Balageas, Stéphane Epelbaum, Alicia Sánchez, Anne Hitzel, Valérie Quipourt, F Bertrand, Marie-Hélène Coste, Michèle Allard, Cécile Pays, Jean-Marc Michel, Adrien Julian, Sophie Marilier, Delphine Jean, ‪Frederic Blanc‬, Fouzia El Mountassir, Claude Hossein-Foucher, Marie-Dominique Desruet, A. Barthelaix, Alice Keles, Chantal Girtanner, Rénata Ursu, Alexandre Cantan, Jing Xie, Sonia Djober, Pauline Gaffez, Anisse Karoun, Julie Lidier, Lauralee Menier, Marie-Ange Cariot, Salim Gherabli, Anne Chawakilian, Hélène Briault, Rezki Daheb, Susanna Schraen-Maschken
article en
15 citations

Abstract

Results from 2 clinical cohorts suggest that amyloid prevalence varied across cognitive phenotypes and was associated with the diagnostic performance of blood p-tau217 models to determine brain amyloidosis. Comprehensive cognitive phenotyping beyond the basic characterization of SCI, MCI, or dementia should accompany the use of blood biomarkers in clinical practice to avoid misdiagnosis due to false positives.

JAMA NeurologyVol. 82(5)
Centre National de la Recherche Scientifique (FR), Université de Bordeaux (FR), Inserm (FR), Université de Montpellier (FR), Université Paris Cité (FR), Université de Lille (FR), Sahlgrenska University Hospital (SE), Centre Hospitalier Universitaire de Bordeaux (FR), Centre Hospitalier Universitaire de Lille (FR), Sorbonne Université (FR), Institut des Maladies Neurodégénératives (FR), Sorbonne Paris Cité (FR), Assistance Publique – Hôpitaux de Paris (FR), Bordeaux Population Health (FR), Hôpital Broca (FR), Immunology from Concept and Experiments to Translation (FR), Pitié-Salpêtrière Hospital (FR), Institut du Cerveau (FR), Centre d'Investigation Clinique Plurithématique de Bordeaux, University of Gothenburg (SE)
Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation, Institut National de la Santé et de la Recherche Médicale, Université de Bordeaux, Fondation pour la Recherche sur Alzheimer
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Dementia and Cognitive Impairment Research
22.07
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