Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model
A modified neonatal rat model of pulmonary vein stenosis (PVS) via bilateral pulmonary vein banding was introduced for the first time, providing a platform for understanding the pathophysiology of PVS and developing treatments. In addition, using this model, the mTOR inhibitor sirolimus was evaluated as a treatment for PVS and exhibited significant therapeutic effects, indicating the need for accelerated ethics approval in clinical settings where sirolimus is not yet in use.
Authors
- Sixie Zheng (ORCID: https://orcid.org/0000-0001-6603-7947)
- Peisen Ruan
- Chun Shen (ORCID: https://orcid.org/0000-0001-6993-4336)
- Sijuan Sun (ORCID: https://orcid.org/0000-0001-5514-2899)
- Lincai Ye (ORCID: https://orcid.org/0000-0001-8808-2810)
- Yi Yan (ORCID: https://orcid.org/0000-0003-2860-3252)
- Hao Chen (ORCID: https://orcid.org/0009-0001-6480-7976)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-0206-9066)
- Qi Sun (ORCID: https://orcid.org/0000-0001-5182-4278)
- Zheng Wang (ORCID: https://orcid.org/0000-0001-8561-6856)
- Yuqing Hu (ORCID: https://orcid.org/0000-0002-9093-1356)
- Debao Li
- Yingying Xiao (ORCID: https://orcid.org/0009-0008-9279-7489)
- Zhenyu Wan (ORCID: https://orcid.org/0000-0001-6413-6765)
Institutions
- Ningbo University (CN)
- University of Electronic Science and Technology of China (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Medical Center (CN)
- Children's Hospital of Fudan University (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1016/j.jacbts.2025.01.010
- Citations
- 2
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China