Review of acamprosate pharmacokinetics and dosing strategies

Adherence to pharmacotherapy for AUD is challenging and difficult to measure. A reduced dose regimen may be appropriate for patients who struggle with the pill burden of traditional doses, though the varying number of tablets required at different times may still pose adherence issues. The bioequivalence of reduced frequency dose to traditional dose suggests it could be a viable option for patients who find a 3-time daily frequency cumbersome. However, the lack of data on the clinical efficacy of reduced frequency makes it difficult to recommend as a primary regimen. Further research is needed to determine if either reduced dose or reduced frequency regimens could improve patient adherence compared with a traditional dose.