Canumycins A–E, Macrocyclic Napyradiomycins from a Marine-Derived <i>Streptomyces canus</i>
Five new macrocyclic napyradiomycins with different types of scaffolds were isolated from marine-derived <i>Streptomyces canus</i> SJ-019. Compounds <b>1</b> and <b>2</b> are uniquely typified by a spirocyclic core, while <b>1</b>, <b>2</b> and <b>4</b> also contain a unique macrolide structure not known in any other napyradiomycins. Compound <b>3</b> is composed of a dearomatized napyradiomycin core and an intramolecular double-arch bridge system. Compound <b>4</b> displays potent inhibition of <i>Staphylococcus aureus</i>, while C-type napyradiomycin <b>5</b> shows notable anti-inflammatory effect.
Authors
- Min Hao (ORCID: https://orcid.org/0009-0001-2970-3637)
- Gui‐Ge Hou (ORCID: https://orcid.org/0000-0002-9493-3981)
- Wei Guo (ORCID: https://orcid.org/0000-0003-3127-2394)
- Cheng‐Lei Qu
- Maolei Xu (ORCID: https://orcid.org/0000-0001-5318-1018)
- Tianyun Jin
- Zeping Xie (ORCID: https://orcid.org/0000-0003-1164-5333)
- Lijuan Kou
- Pei Wang (ORCID: https://orcid.org/0000-0002-0221-7858)
- Lin Guo (ORCID: https://orcid.org/0000-0002-6070-2384)
- Shumin Zhang (ORCID: https://orcid.org/0000-0002-9030-8070)
- Yuan Deng (ORCID: https://orcid.org/0000-0001-8425-6326)
Institutions
- Binzhou Medical University (CN)
- Scripps Institution of Oceanography (US)
- Shandong University of Aeronautics (CN)
- University of California San Diego (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c00472
- Citations
- 3
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 4.18