Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy
MIR503HG plays a role in ventricular chamber development, and its deletion leads to an LVNC phenotype independent of the miRNA cluster within its locus, highlighting its importance in cardiac development and disease. We further suggest that abnormal Notch1 activity may underpin the LVNC phenotype presented.
Authors
- Abdelaziz Beqqali (ORCID: https://orcid.org/0000-0003-1390-5821)
- Kevin Stewart (ORCID: https://orcid.org/0000-0003-4579-6826)
- Julie Rodor (ORCID: https://orcid.org/0000-0003-2900-5780)
- João P Monteiro (ORCID: https://orcid.org/0000-0001-6481-6875)
- Ana‐Mishel Spiroski (ORCID: https://orcid.org/0000-0002-8584-8048)
- Dyana Markose (ORCID: https://orcid.org/0000-0002-4739-8509)
- Thomas Quertermous (ORCID: https://orcid.org/0000-0002-7645-9067)
- Gonzalo del Monte‐Nieto (ORCID: https://orcid.org/0000-0003-3830-2226)
- Sankaranarayana P. Mahesh
- Richard P. Harvey (ORCID: https://orcid.org/0000-0002-9950-9792)
- Nicholas Murray (ORCID: https://orcid.org/0000-0002-4008-3053)
- Adrian Thomson (ORCID: https://orcid.org/0000-0001-7320-300X)
- Dónal O’Carroll (ORCID: https://orcid.org/0000-0002-8626-2217)
- Andrew Howard Baker (ORCID: https://orcid.org/0000-0003-1441-5576)
- Azzurra Laura De Pace (ORCID: https://orcid.org/0000-0003-2121-7068)
- Francesco Severi (ORCID: https://orcid.org/0000-0003-2186-8274)
- Vaibhao Janbandhu (ORCID: https://orcid.org/0000-0002-3837-1865)
- Patrick W. F. Hadoke (ORCID: https://orcid.org/0000-0002-1041-1781)
- John R. Wilson‐Kanamori (ORCID: https://orcid.org/0000-0002-1372-9912)
- Matthew Bennett (ORCID: https://orcid.org/0000-0001-9819-3397)
- Diptarka Saha (ORCID: https://orcid.org/0009-0001-4731-4328)
- Neil Cowan Henderson (ORCID: https://orcid.org/0000-0002-2273-4094)
- Peter Kaltzis (ORCID: https://orcid.org/0000-0003-2790-6606)
- S. González Sánchez (ORCID: https://orcid.org/0000-0003-4406-1158)
- Abhijit Nadavallil
Institutions
- Victor Chang Cardiac Research Institute (AU)
- Maastricht University Medical Centre (NL)
- Australian Regenerative Medicine Institute (AU)
- University Medical Center (US)
- UNSW Sydney (AU)
- Maastricht University (NL)
- MRC Centre for Regenerative Medicine (GB)
- Regenerative Medicine Institute (MX)
- Centre for Inflammation Research (GB)
- Institute of Genetics and Cancer (GB)
- The Queen's Medical Research Institute (GB)
- Monash University (AU)
- Stanford University (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-03-30
- DOI
- https://doi.org/10.1093/cvr/cvaf043
- Citations
- 7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- British Heart Foundation
- National Heart Foundation of Australia
- Medical Research Council
- Australian Research Council
- National Health and Medical Research Council