Feasibility study of using fast low-dose pencil beam proton and helium radiographs for intrafractional motion management
This study demonstrates that low-dose small-field proton and helium radiography, utilizing pencil beam scanning, can effectively monitor intrafractional anatomical displacements with millimeter-level spatial accuracy and sub-second temporal resolution. Current particle imaging and beam delivery technologies have the potential to enable real-time patient monitoring in promising mixed ion beam therapy.
Authors
- Ethan A. DeJongh (ORCID: https://orcid.org/0000-0001-6847-7997)
- Alexander Pryanichnikov (ORCID: https://orcid.org/0000-0001-7959-1808)
- Oliver Jäkel
- L. Martín (ORCID: https://orcid.org/0000-0002-2514-0646)
- Don F. DeJongh (ORCID: https://orcid.org/0000-0003-2285-5360)
- João Seco
- Niklas Wahl (ORCID: https://orcid.org/0000-0002-1451-223X)
- Jennifer Hardt (ORCID: https://orcid.org/0000-0001-8827-3094)
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Heidelberger Institut für Radioonkologie (DE)
- ProtonVDA (United States) (US)
Publication Details
- Journal
- Physica Medica
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1016/j.ejmp.2025.104959
- Citations
- 1
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Deutsche Forschungsgemeinschaft