Longitudinal Relationship Between Elevated Liver Biochemical Tests and Negative Clinical Outcomes in Primary Biliary Cholangitis: A Population‐Based Study
Prolonged elevation of multiple hepatic biomarkers and fibrosis scores is associated with a greater risk of negative clinical outcomes, underscoring the importance of ongoing monitoring beyond the guideline-recommended initial treatment response to guide timely treatment decisions and improve PBC management.
Authors
- Leona Bessonova (ORCID: https://orcid.org/0000-0002-3893-7910)
- Joanna P. MacEwan (ORCID: https://orcid.org/0000-0003-2702-1170)
- Gideon M. Hirschfield (ORCID: https://orcid.org/0000-0002-6736-2255)
- David W. Victor (ORCID: https://orcid.org/0000-0003-1414-3128)
- Alina Levine
- Jennifer Hernandez
- Darren Wheeler
- Kris V. Kowdley (ORCID: https://orcid.org/0000-0002-8553-3652)
- Jing‐Feng Li (ORCID: https://orcid.org/0000-0002-0185-0512)
- Radhika Nair (ORCID: https://orcid.org/0000-0003-1404-4496)
Institutions
- Toronto General Hospital (CA)
- Methodist Hospital (US)
- Liver Institute Northwest (US)
- Intercept Pharmaceuticals (United States) (US)
- Washington State University (US)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1111/apt.70120
- Citations
- 2
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- Intercept Pharmaceuticals