Caffeic acid and chlorogenic acid mediate the ADPN-AMPK-PPARα pathway to improve fatty liver and production performance in laying hens
This study demonstrates that dietary CA and CGA effectively improve laying performance, egg quality, and hepatic lipid metabolism in laying hens, with CA potentially being more economical and efficient. Transcriptomic and proteomic evidence highlight shared mechanisms between CA25 and CGA100. These findings provide a foundation for CA and CGA as therapeutic agents for fatty liver disease and related metabolic diseases in hens, and also offer insights into the targeted modification of CGA (including the isomer of CGA) into CA, thereby providing novel strategies for the efficient utilization of CGA.
Authors
- Qingyu Zhao (ORCID: https://orcid.org/0000-0002-4123-4503)
- Huiyan Zhang (ORCID: https://orcid.org/0000-0002-4818-7156)
- Chaohua Tang
- Wenjie Tian (ORCID: https://orcid.org/0000-0002-4328-0255)
- Gerard Bryan Gonzales (ORCID: https://orcid.org/0000-0001-6614-3520)
- Hao Wang (ORCID: https://orcid.org/0000-0002-0900-5807)
- Youyou Yang
- Junmin Zhang
- Yuchang Qin (ORCID: https://orcid.org/0000-0003-0171-9597)
Institutions
- Ghent University (BE)
- Chinese Academy of Agricultural Sciences (CN)
- Institute of Animal Sciences (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1186/s40104-025-01175-z
- Citations
- 6
- Primary Topic
- Animal Nutrition and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 7.16
Funders
- National Key Research and Development Program of China