Predicting cardiovascular morbidity and mortality with SCORE2 (OP) and Framingham risk estimates in combination with indicators of biological ageing
We show robust evidence that a higher FI value at baseline is associated with an increased risk of incident CVD in middle-aged and older CVD-free individuals, also when simultaneously considering the risk according to the FRS or SCORE2/SCORE2-OP. The FI improved the predictive accuracy of CVD outcomes beyond the traditional CVD risk indicators and demonstrated satisfactory predictive accuracy even when used independently.
Authors
- Linda Enroth (ORCID: https://orcid.org/0000-0001-6613-3154)
- Johan G. Eriksson (ORCID: https://orcid.org/0000-0002-2516-2060)
- Jani Raitanen (ORCID: https://orcid.org/0000-0001-7674-0978)
- Markus J. Haapanen (ORCID: https://orcid.org/0000-0002-8632-7906)
- Laura Kananen (ORCID: https://orcid.org/0000-0003-3742-8927)
- Iiris Hovatta (ORCID: https://orcid.org/0000-0002-5990-7892)
- Juulia Jylhävä (ORCID: https://orcid.org/0000-0003-0250-4491)
- Anna Tirkkonen (ORCID: https://orcid.org/0000-0002-9477-2356)
- Mikaela B. von Bonsdorff (ORCID: https://orcid.org/0000-0001-8530-5230)
- Tuija Jääskeläinen (ORCID: https://orcid.org/0000-0001-6263-2298)
- Sara Hägg (ORCID: https://orcid.org/0000-0002-2452-1500)
- Jonathan K. L. Mak (ORCID: https://orcid.org/0000-0003-4454-8580)
- Pauliina Halonen (ORCID: https://orcid.org/0000-0002-0890-208X)
- Seppo Koskinen (ORCID: https://orcid.org/0000-0003-1572-1735)
Institutions
- University of Helsinki (FI)
- Tampere University of Applied Sciences (FI)
- National University of Singapore (SG)
- Tampere University (FI)
- Helsinki University Hospital (FI)
- Karolinska Institutet (SE)
- Finnish Institute for Health and Welfare (FI)
- Tampere University (FI)
- Folkhälsans Forskningscentrum (FI)
- Urho Kaleva Kekkonen Institute (FI)
- University of Hong Kong (HK)
- University of Jyväskylä (FI)
Publication Details
- Journal
- Age and Ageing
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1093/ageing/afaf075
- Citations
- 3
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 3.67