Pathological Characterisation of Posterior Cortical Atrophy in Comparison With Amnestic Alzheimer's Disease
This study demonstrates differences in the distribution of Aβ and tau and variations in regional neuroinflammatory response in PCA-AD and a-AD. These findings extend our understanding of the biological substrates underpinning PCA-AD and highlight the potential for exploring phenotypic variants to understand selective vulnerability in neurodegenerative diseases.
Authors
- Z. Abdi (ORCID: https://orcid.org/0000-0002-8979-5262)
- Sebastian J. Crutch (ORCID: https://orcid.org/0000-0002-4160-0139)
- Jonathan M. Schott (ORCID: https://orcid.org/0000-0003-2059-024X)
- Tammaryn Lashley (ORCID: https://orcid.org/0000-0001-7389-0348)
- Alfred Gatt (ORCID: https://orcid.org/0000-0002-0489-6479)
- Keir Xin Xian Yong
- T. Révész
Institutions
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/nan.70007
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Alzheimer's Association
- Weston Brain Institute
- Brain Research UK
- Alzheimer's Society
- National Institute for Health and Care Research
- British Heart Foundation
- Dunhill Medical Trust
- University College London
- UK Dementia Research Institute
- Medical Research Council