Plasma Microbial Cell-free DNA Metagenomic Sequencing for Diagnosis of Invasive Fungal Diseases Among High-risk Outpatient and Inpatient Immunocompromised Hosts
A positive result by mcfDNA sequencing may reduce the need for invasive sampling in patients with suspected IFD. In this exploratory analysis, its high sensitivity and specificity for invasive mucormycosis suggests it could be useful for early treatment and intervention of this IFD. Future studies should focus on understanding how specific factors impact the sensitivity of mcfDNA sequencing for invasive aspergillosis.
Authors
- Barbara D. Alexander (ORCID: https://orcid.org/0000-0001-5868-0529)
- Jordan Mah (ORCID: https://orcid.org/0000-0002-7552-4840)
- David R. Andes (ORCID: https://orcid.org/0000-0002-7927-9950)
- Kimberly E. Hanson (ORCID: https://orcid.org/0000-0001-9790-277X)
- Kelly Stanly
- Madeleine R. Heldman (ORCID: https://orcid.org/0000-0002-9424-1870)
- Beatrice Sim (ORCID: https://orcid.org/0000-0003-1845-4476)
- Angela M. Caliendo (ORCID: https://orcid.org/0000-0003-4309-7642)
- Luis Ostroskly-Zeichner
Institutions
- University of Wisconsin System (US)
- Texas Medical Center (US)
- University of Wisconsin–Madison (US)
- Duke University (US)
- University of Utah (US)
- Brown University (US)
- University of Florida (US)
- ARUP Laboratories (United States) (US)
- ARUP Laboratories (United States) (US)
- The University of Texas Health Science Center at Houston (US)
- Florida College (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1093/cid/ciaf170
- Citations
- 7
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 9.77